Single-Molecule Manipulation Experiments

Our research focuses on understanding the interactions of biological molecules and complexes. We use atomic force microscopy to study the forces between and within single biological molecules. The development of single-molecule techniques to studying molecular properties at the molecular level has expanded our understanding on the details of how biology and medicine function at the microscopic level. We are studying protein-nucleic interactions, virus assemblies, and protein-cell interactions. as well as developing new nanomanipulation techniques to study the properties of single-molecules.